Epidemiology and Health

Cohort Profile

The Dehgolan Prospective Cohort Study (DehPCS) on non-communicable diseases in a Kurdish community in the west of Iran: Farhad Moradpour, Ebrahim Ghaderi, Ghobad Moradi, Mojdeh Zarei, Amjad Mohamadi Bolbanabad, Bakhtiar Piroozi, Azad Shokri; Epidemiol Health. 2021;43:e2021075. Published online October 1, 2021; DOI: https://doi.org/10.4178/epih.e2021075

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Abstract

The Dehgolan Prospective Cohort Study (DehPCS) was conducted to examine and identify risk factors for the most prevalent non-communicable diseases (NCDs). In addition, in order to examine participants’ health status, socioeconomic status, behavioral factors, nutritional status, and environmental exposures, the DehPCS collected, analyzed, and stored blood, urine, nail, and hair samples to conduct genetic studies and identify biomarkers and other biological determinants of NCDs. In total, 3,996 adults aged 35 to 70 from the general population participated in the study from February 2018 to March 2019. Of them, 43.7% were women. The first follow-up wave was conducted with 3,995 participants. Information on a wide range of variables was collected, including on socioeconomic status, lifestyle, nutritional status, habits, physical examination findings, medication use, and medical history. Proxy variables such as body mass index, metabolic equivalent task score, wealth index, and macronutrients and micronutrients were calculated. The most common self-reported diseases in descending order were kidney stones, hypertension, and fatty liver. The prevalence of diabetes and hypertension was 9.3% and 33.4%, respectively. All data, samples, and measurements will be collected again at 5-year intervals. Thus, it will be possible to examine time-dependent changes in the risk factors of NCDs. The DehPCS can be used to study the relationships among genetics, lifestyle, socioeconomic status, and environmental risk factors and the most prevalent NCDs in case-cohort studies using a nested case-control design that will be applied to the cohort infrastructure. Researchers can also submit pre-proposals via the following web address: http://c.ddrc.ac.ir/persianaccess/Account/Login.

Summary

Key Message
• The DehPCS was designed to examine NCDs among the Kurdish population, who are located in a wide area between the northwest of the Zagros Mountains and the eastern Taurus Mountains covering Turkey, Iraq, Iran, and Syria. • In total, 3,996 adults aged 35 to 70 from the general population participated in the study. • All data, samples, and measurements from the registration phase will be collected again at 5-, 10-, and 15-year intervals. • After labeling, aliquots were placed in a freezer at -70°C to enable ongoing studies of the samples in the future.

Citations

Citations to this article as recorded by

Validity of self‐reported hypertension and related factors in the adult population: Preliminary results from the cohort in the west of Iran
Negar Piri, Yousef Moradi, Reza Ghanei Gheshlagh, Mahsa Abdullahi, Eghbal Fattahi, Farhad Moradpour
The Journal of Clinical Hypertension.2023; 25(2): 146. CrossRef
The association between nutrients and occurrence of COVID‐19 outcomes in the population of Western Iran: A cohort study
Dana Vaisi, Farhad Moradpour, Shadieh Mohammadi, Daem Roshani, Yousef Moradi
The Clinical Respiratory Journal.2023; 17(6): 589. CrossRef
Prevalence of metabolic syndrome and its association with oral health: First results from the Kurdish cohort study
Farhad Moradpour, Zahra Karimi, Zeinab Fatemi, Yousef Moradi, Mohammad Rastegar Khosravi, Azad Shokri, Mohammad Karimzadeh
Health Science Reports.2023;[Epub] CrossRef
Socioeconomic inequalities in metabolic syndrome and its components in a sample of Iranian Kurdish adults
Pardis Mohammadzadeh, Farhad Moradpour, Bijan Nouri, Farideh Mostafavi, Farid Najafi, Ghobad Moradi
Epidemiology and Health.2023; 45: e2023083. CrossRef
Socio-demographic correlates of diabetes self-reporting validity: a study on the adult Kurdish population
Farhad Moradpour, Negar Piri, Hojat Dehghanbanadaki, Ghobad Moradi, Mahdiyeh Fotouk-Kiai, Yousef Moradi
BMC Endocrine Disorders.2022;[Epub] CrossRef
Prevalence of prediabetes, diabetes, diabetes awareness, treatment, and its socioeconomic inequality in west of Iran
Farhad Moradpour, Satar Rezaei, Bakhtiar Piroozi, Ghobad Moradi, Yousef Moradi, Negar Piri, Azad Shokri
Scientific Reports.2022;[Epub] CrossRef

Original Article

Comparison of the tuberculin skin test and the QuantiFERON-TB Gold test in detecting latent tuberculosis in health care workers in Iran: Ehsan Mostafavi, Mahshid Nasehi, Abdolrazagh Hashemi Shahraki, Saber Esmaeili, Ebrahim Ghaderi, Saeed Sharafi, Amin Doosti-Irani; Epidemiol Health. 2016;38:e2016032. Published online July 24, 2016; DOI: https://doi.org/10.4178/epih.e2016032

16,211 View
220 Download
9 Web of Science
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Abstract PDF

Abstract

OBJECTIVES
The tuberculin skin test (TST) and the QuantiFERON-TB Gold test (QFT) are used to identify latent tuberculosis infections (LTBIs). The aim of this study was to determine the agreement between these two tests among health care workers in Iran.

METHODS

This cross-sectional study included 177 tuberculosis (TB) laboratory staff and 67 non-TB staff. TST indurations of 10 mm or more were considered positive. The Student’s t-test and the chi-square test were used to compare the mean score and proportion of variables between the TB laboratory staff and the non-TB laboratory staff. Kappa statistics were used to evaluate the agreement between these tests, and logistic regression was used to assess the risk factors associated with positive results for each test.

RESULTS

The prevalence of LTBIs according to both the QFT and the TST was 17% (95% confidence interval [CI], 12% to 21%) and 16% (95% CI, 11% to 21%), respectively. The agreement between the QFT and the TST was 77.46%, with a kappa of 0.19 (95% CI, 0.04 to 0.34).

CONCLUSIONS

Although the prevalence of LTBI based on the QFT and the TST was not significantly different, the kappa statistic was low between these two tests for the detection of LTBIs.

Summary

Citations

Citations to this article as recorded by

Tuberculin test using Indian indigenous purified-protein derivative (PPD) shows only moderate agreement with international standard PPD
Devasahayam J. Christopher, N. Priya, Deepa Shankar, Barney Isaac, Andrea DeLuca, Sonali Sarkar, Senbagavalli Prakash Babu, Prasanna Samuel, Adithya Cattamanchi, Amita Gupta, Jerrold Ellner, Sudha Srinivasan, Samyra Cox, Balamugesh Thangakunam
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases.2024; 34: 100404. CrossRef
Meta-analysis of latent tuberculosis in healthcare workers in Iran: a retrospective review
NazaninZahra Sepehri, Seyed Mohammad Saghanezhad, Farshad Khoddami, Amin Arasteh, Marziyeh Delirakbariazar, Azad Khaledi
Transactions of The Royal Society of Tropical Medicine and Hygiene.2021; 115(9): 965. CrossRef
Risk of Occupational Latent Tuberculosis Infection among Health Personnel Measured by Interferon-Gamma Release Assays in Low Incidence Countries—A Systematic Review and Meta-Analysis
Claudia Peters, Agnessa Kozak, Albert Nienhaus, Anja Schablon
International Journal of Environmental Research and Public Health.2020; 17(2): 581. CrossRef
Latent tuberculosis infection in healthcare workers in low- and middle-income countries: an updated systematic review
Lika Apriani, Susan McAllister, Katrina Sharples, Bachti Alisjahbana, Rovina Ruslami, Philip C. Hill, Dick Menzies
European Respiratory Journal.2019; 53(4): 1801789. CrossRef
Latent Tuberculosis Infection among Healthcare Workers in Duhok Province: From Screening to Prophylactic Treatment
Hind Bahzad Almufty, Ibtesam Salih Abdulrahman, Muayad Aghali Merza
Tropical Medicine and Infectious Disease.2019; 4(2): 85. CrossRef
Is latent tuberculosis infection challenging in Iranian health care workers? A systematic review and meta-analysis
Mohammad Hossein YektaKooshali, Farahnaz Movahedzadeh, Ali Alavi Foumani, Hoda Sabati, Alireza Jafari, HASNAIN SEYED EHTESHAM
PLOS ONE.2019; 14(10): e0223335. CrossRef
Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: A latent-class analysis
Tan N. Doan, Damon P. Eisen, Morgan T. Rose, Andrew Slack, Grace Stearnes, Emma S. McBryde, Lei Gao
PLOS ONE.2017; 12(11): e0188631. CrossRef
Prevalence of latent tuberculosis infection among tuberculosis laboratory workers in Iran
Mahshid Nasehi, Abdolrazagh Hashemi-Shahraki, Amin Doosti-Irani, Saeed Sharafi, Ehsan Mostafavi
Epidemiology and Health.2016; 39: e2017002. CrossRef

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